Interpretation of HBV serological markers: ie. How to diagnose what is the present situation of patient with hepatitis B, regarding to its serological finding
|
|
Anti HBc |
AntiHBe IgM |
HBsAg |
HBsAb(antibody) |
HBeAg |
HBeAb |
| Acute | + | + | + | – | + ; – | – |
| Persistant Carrier | + | – | + | – | + ; – | + ; – |
| Recovery/immunity | – | – | – | + | – | + |
| Vaccine | – | – | – | + | – | – |
|
A |
B |
C |
D (delta) |
E |
|
|
TYPE of VIRUS |
Picornavirus; RNA type; size: 27 -32nm | HepaDNAvirus; DNA double stranded type; size 27-32nm | Flavivirus; RNA with serotypes C1 to C6 | RNA type; hepatitis B DNA required for replication | Non-A non-B virus |
| Incubation Period | 14 – 45 days | 1 – 6 monhs (longest) | 14 – 180days | 1-6months | 2-20weeks |
| Mechanism of SPREAD | Fecal-oral; often Epidemic; blood exposure; person- person | Parenteral (blood); Vertical (mother to fetus); Drug abuser; person – person | Blood; vertical; sexual | Blood; Vertical; Sexual | Epidemic/Endemic; blood; vertical; Sexual |
| Antigens | HAAg / HAV ag | HBVag / HBsAg(carrier) | – | – | – |
| Antibodies | AntiHAV; IgM | IgM; antiHBsAb; IgG; antiHBe | AntiHCV; IgM | IgM; HDVab | – |
| Complications | Fulminant hepatitis | -do- | -do- | -do- | -do- |
| CarrierState | NO | YES | YES | YES | NO |
| Chronic Liver Disease | NO | YES | YES | YES | NO |
| LIVER CANCER | No | YES | YES | rare | No |
| IMMUNIZATION
a- Active b- Passive |
a- Yes (inactivated VHA vaccine)
b- Immune Serum glubulin |
a- vaccine HBsAg to all 0 – 18age
b- immune serum globulin |
a- No
b- Immunoprophylaxis |
Prevention by preventing hepatitis B | a- No
b- immunoprophylaxis |
| Extra Treatment | Hepatoprotector | hepatoprotector | Interferon | hepatoprotector | Interferon |
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